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Yuan Fang
M.Sc. Program
Previous Degree: B.Sc. Cell Biology & Genetics
2009 Cohort

M.Sc. thesis defense: Wednesday, July 25, 2012

Salmonella enterica, an intracellular bacteria pathogen that causes enteritis and typhoid fever, is an important model organism for studying host-pathogen interactions. Salmonella has two Type 3 Secretion Systems (T3SS) encoded on Salmonella Pathogenecity Islands (SPI) that inject effector proteins directly into the host cell to modulate invasion (SPI-1) and intracellular survival (SPI-2). I am using mass spectrometry-based proteomic tools to map the global phosphorylation events in Salmonella and to explore the correlation between bacterial phosphorylation and Salmonella virulence.

Supervisor: Leonard Foster