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Mimi Brown
M.Sc. Program
Previous Degree: B.Sc. Biochemistry

2010 Cohort

The interface of evolving host-pathogen systems has traditionally been approached from a reductionist perspective. Threads of a canvas, these studies weave together a biological framework to support our current understanding of Salmonella’s complex pathogenesis. During infection, Salmonella utilizes a type three-secretion system to inject effector proteins into the host cell that effectively hijacks the cell’s machinery. To construct a picture of these global shifts in host cells, a high throughput method for monitoring dynamic protein-protein interactions, PP-SILAC, was applied to this host-pathogen system for the first time. Further work on this project will involve integrating this dataset with a phosphoproteomic study performed by a previous lab member.

Supervisor: Leonard Foster