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Dr. Robert Holt
Department of Psychiatry
Genome Sciences Centre

Immunology/Neurobiology/Synthetic Biology/Evolutionary Biology/DNA Sequencing

We are developing Next Generation Sequencing approaches for studying the complexity of the adaptive immune system in healthy individuals, and the ways in which this is disturbed by infectious disease, cancer, transplantation and normal ageing. We are also screening for novel infectious agents and mutations that may cause cancer or autoimmune disorders and we are working on new methods for vaccination using this information. The group has an ongoing interest in Synthetic Biology, where we are developing technology for gene and genome synthesis. We have an established pipeline for building DNA constructs used in gene therapy research.

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