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Dr. Pamela Hoodless
Department of Medical Genetics
BC Cancer Research Centre

Mammalian Development and the Signalling Pathways That Regulated These Processes

Establishing the body plan of an embryo requires complex cell-cell communication networks. Organizing centers have been identified in the embryo which act as initiating sources for signaling networks and direct surrounding cells into appropriate patterns. Two distinct organizing centers are found in early mammalian embryos, the anterior visceral endoderm (AVE), which is required for head structures, and the node, which coordinates the body. How these organizers are formed and how they function to pattern the embryo remains poorly understood.

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