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Dr. Michel Roberge
Department of Biochemistry & Molecular Biology

Regulation of Mitosis and Cancer Therapy

Entry into and progression through mitosis are controlled by protein kinases and phosphatases, only some of which have been identified. When DNA is damaged, cells activate a checkpoint which blocks entry into mitosis and whose mechanism is little known. Cancer cells have weakened checkpoints, a major cause of their characteristic genomic instability. To develop novel approaches to cancer therapy, we wish to exploit this difference between normal and cancer cells.

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